Characterisation of Osteoprotegerin Autoantibodies in Coeliac Disease
نویسندگان
چکیده
منابع مشابه
Autoantibodies to gliadin-binding 90 kDa glycoprotein in coeliac disease.
Patients with untreated coeliac disease were found to have high concentrations of circulating antibodies to 90 kDa glycoprotein, a mannose rich protein found in skin and intestinal mucosa. In contrast, patients with active Crohn's disease or ulcerative colitis had antibody concentrations within the normal range. In coeliac disease the antibody concentrations fell significantly after gluten with...
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Endomysial antibodies are a hallmark of coeliac disease. The existence of autoantibodies whose titres fluctuate with ingestion of gliadin is enigmatic.Gliadin seems to drive this antibody secretion as endomysial antibodies are produced in biopsy samples cultured with a peptic/tryptic digest of gliadin. The phenomenon of endomysial antibodies has been explained by molecular mimicry between gliad...
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A 4-year-old boy presented with occipital seizures but normal initial neuroimaging and proved refractory to antiepileptic medications. On repeat neuroimaging after 1 year, he had developed bi-occipital calcification and was then found to have positive coeliac serology. He was diagnosed with coeliac disease, epilepsy, and cerebral calcifications (CEC) and became seizure free after starting the g...
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Serum IgA class reticulin autoantibody test was performed prospectively once a year on 238 children and adolescents with insulin dependent diabetes mellitus (IDDM). At the initial testing, within one year after onset of IDDM, five were positive and 233 were negative. During follow up a further 11 of the initially antibody negative children became positive (6.7%). Jejunal biopsy was performed at...
متن کاملAutoantibodies of patients with coeliac disease are insufficient to block tissue transglutaminase activity.
BACKGROUND AND AIMS Coeliac disease (CD) is characterised by the presence of autoantibodies against tissue transglutaminase (tTG), the endomysial autoantigen. This study was performed to determine the effect of purified autoantibodies on the enzymatic activity of tTG. METHODS Total IgA and IgG class antibodies and purified anti-tTG autoantibodies were isolated from sera of untreated patients ...
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ژورنال
عنوان ژورنال: Calcified Tissue International
سال: 2015
ISSN: 0171-967X,1432-0827
DOI: 10.1007/s00223-015-0023-4